- Original Article
- Clinical significance of loss of p16 protein by immunohistochemical
staining in acute lymphoblastic leukemia
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Hye Young Jin, Kyoung In Kang, Sun Young Kim, You Sook Youn, Joon Won Kang, Deog Yeon Jo, Kye Chul Kwon, Kyung Duk Park
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Clin Exp Pediatr. 2008;51(1):73-77. Published online January 15, 2008
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Purpose : p16 gene, mapped to the 9p21 chromosomal region, has emerged as a candidate tumor suppressor gene in human neoplasm. It is an inhibitor of cyclin-dependent kinase and inhibits Rb phosphorylation. In a variety of tumors including childhood acute lymphoblastic leukemia (ALL), deletion and/or mutation of the p16 gene has been found. Despite their high frequency, the prognostic importance... |
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